Azide-PEG3-Desthiobiotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Product information

CAS Number: 1426828-06-9

Molecular Weight: 414.50

Formula: C18H34N6O5

Chemical Name: N-(2-{2-[2-(2-azidoethoxy)ethoxy]ethoxy}ethyl)-6-(5-methyl-2-oxoimidazolidin-4-yl)hexanamide

Smiles: CC1NC(=O)NC1CCCCCC(=O)NCCOCCOCCOCCN=[N+]=[N-]

InChiKey: JIQVKRRASYKCEL-UHFFFAOYSA-N

InChi: InChI=1S/C18H34N6O5/c1-15-16(23-18(26)22-15)5-3-2-4-6-17(25)20-7-9-27-11-13-29-14-12-28-10-8-21-24-19/h15-16H,2-14H2,1H3,(H,20,25)(H2,22,23,26)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Products are for research use only. Not for human use.